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KMID : 0380620140460020245
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Korean Journal of Food Science and Technology
2014 Volume.46 No. 2 p.245 ~ p.248
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The Antiviral Effects of Areca catechu L. Extract
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Lee Do-seung
Boo Kyung-Hwan
Kim Young-Cheon
Lee Jin-Man
Kang Syung-Tae
Lee Wang-Shik
Riu Key-Zung
Lee Dong-Sun
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Abstract
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Trafficking of viral glycoproteins to the cell surface results in syncytium formation in baby hamster kidney(BHK) cells infected with Newcastle disease virus (NDV). An extract from the medicinal Areca catechu L plant inhibitednot only syncytium formation, but also trafficking of the hemagglutinin-neuramidase (HN) glycoprotein to the cell-surface.The viral glycoprotein was processed within the endoplasmic reticulum during transit to the cell membrane. Fungal extractsshowed inhibitory activities (IC50 10 μg/mL) against α-glucosidase. These results suggested that A. catechu L. extractsinhibited the cell-surface expression of NDV-HN glycoprotein without significantly affecting HN glycoprotein synthesis inNDV-infected BHK cells.
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KEYWORD
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methanol extract of A. catechu, α-glucosidase inhibition, antiviral activities
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